Results 131 to 140 of about 9,036,555 (399)

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Analysis of risks in a Learning Management System: A case study in the Spanish National University of Distance Education (UNED)

Journal of New Approaches in Educational Research, 2015
This article presents a research that examines the university students' risk perception when using a Learning Management System called “aLF” and implemented by the Spanish National University of Distance Education (UNED) for the development of its ...
Esteban Vázquez Cano, M.ª Luisa Sevillano García   +1 more
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

The Empowerment of Orang Asli Women in the Tourism Industry in Lenggong, Perak

SHS Web of Conferences, 2014
Women, particularly those of the Orang Asli community, without a doubt play an important role in the family. These duties and roles include organising household affairs, giving birth and raising children, tending to the house, preparing meals for the ...
Yahaya Fatan Hamamah, Yahaya Liyana Syafiqah   +1 more
doaj   +1 more source

An OER online course remixing experience

Open Praxis, 2015
This paper describes the authors’ experience of remixing two existing OER courses to provide an OER course for a particular purpose and context. The developing country target environment is stated as well as the original resources’ provenance.
Brenda Justine Mallinson, Greig Emil Krull   +1 more
doaj   +1 more source

The Quality Of Service Of The Distance Education

Procedia - Social and Behavioral Sciences, 2013
AbstractThe purpose of this paper is to measure the quality of service of the distance education that received from the educational institutions which are among the leading service enterprises, to find out students’ expectations, to what extend students expectations are met and whether or not the acquired findings vary by demographical information of ...
Dursun, Tolga, Oskaybas, Kader, Gokmen, Cansu   +2 more
openaire   +3 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Revolution, evolution, or regression – the transformation of assessments through times of pandemic and AI

Ubiquity Proceedings
In this paper we will discuss the tensions between, revolution, evolution and regression that are shaping assessment practice in higher education. The two major influences on shaping assessment in higher education in recent years have been: (1) the ...
Stylianos Hatzipanagos, Linda Amrane-Cooper, Alan Tait   +2 more
doaj   +1 more source