Results 131 to 140 of about 1,385,843 (310)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Analyzing Interplant Marginal Abatement Cost Differences: A Directional Output Distance Function Approach

open access: yes
The purpose of this paper is to compute and evaluate producers’ marginal abatement costs (MACs). These costs are obtained by calculating shadow prices of bad outputs from the production technology, which is represented by the estimated directional output
Marklund, Per-Olov
core   +1 more source

The effects of governance changes on bank efficiency in China: A stochastic distance function approach [PDF]

open access: yes
China has accelerated and deepened bank reform since it joined the WTO in 2001. Employing a stochastic distance function, this paper investigates the technical efficiency of banks and examines the static, selection and dynamic effects of governance ...
Chunxia Jiang, Shujie Yao
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

- FIRM-SPECIFIC TEMPORAL VARIATION IN TECHNICAL EFFICENCY RESULTS OF: A STOCHASTIC OUTPUT DISTANCE FUNCTION [PDF]

open access: yes
The aim of this paper is to test the temporal variation of technical efficiency of the Spanish Savings Banks during the period 1985-1994. Furthermore, a stochastic output distance function (Shephard, 1970) is employed to accommodate multiple output ...
Rafael Álvarez Cuesta   +1 more
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

MEASURING THE IMPACT OF FOOD SAFETY REGULATION-AN OUTPUT DIRECTIONAL DISTANCE FUNCTION APPROACH

open access: yes
This paper provides a novel methodology to measure the impact of food safety regulation. An output directional distance function approach is applied to estimate the opportunity cost of food safety regulation.
Cho, Bo-Hyun, Hooker, Neal H.
core   +1 more source

A Bayesian Approach To Imposing Curvature On Distance Functions [PDF]

open access: yes
The estimated parameters of output distance functions frequently violate the monotonicity, quasiconvexity and convexity constraints implied by economic theory, leading to estimated elasticities and shadow prices that are incorrectly signed, and ...
Tim J. Coelli, Chris O'Donnell
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

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