Results 71 to 80 of about 1,385,843 (310)
SystemsThis paper introduces a novel decomposition method for analyzing production efficiency based on the Data Envelopment Analysis framework, addressing the limitations of traditional approaches that often fail to isolate the contributions of individual ...
Tingyang Huang +3 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
On Mahalanobis distance in functional settings
J. Mach. Learn. Res., 2018 27 pages, 4 figures, 3 ...
José R. Berrendero +2 more
openaire +4 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Orientation, distance, regulation and function of neighbouring genes
Human Genomics, 2009 The sequencing of the human genome has allowed us to observe globally and in detail the arrangement of genes along the chromosomes. There are multiple lines of evidence that this arrangement is not random, both in terms of intergenic distances and ...
Gherman Adrian +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Scale Elasticity Measure for Directional Distance Function and its Dual [PDF]
In this paper we introduce a scale elasticity measure based on directional distance function for multi-output-multi-input technologies and explore its fundamental properties.
Valentin Zelenyuk
core
Scientific ReportsDecision-making for engineering systems like multi-path parallel transmission is plagued by ambiguous and asymmetric information. While q-rung orthopair fuzzy sets offer expressive power, their decision-making frameworks face three intertwined gaps: (1 ...
Shanshan Qiu +3 more
doaj +1 more source