Results 41 to 50 of about 246,733 (219)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
European Journal of Combinatorics, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Aleksandar Ilic +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Distance-Regular Graphs and Halved Graphs
European Journal of Combinatorics, 1986 Let G be a bipartite distance-regular graph with bipartition \(V(G)=X\cup Y\). Let \(V(G')=X\) and, for x and y in X, let x be adjacent to y in G' if and only if x is of distance two from y in G. Then G' is called a halved graph of G, and is distance-regular. This paper discusses whether G' is one of the known, large-diameter, distance-regular graphs.
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On the editing distance of graphs [PDF]
Journal of Graph Theory, 2008 AbstractAn edge‐operation on a graph G is defined to be either the deletion of an existing edge or the addition of a nonexisting edge. Given a family of graphs $\cal G$, the editing distance from G to $\cal G$ is the smallest number of edge‐operations needed to modify G into a graph from $\cal G$.
Maria Axenovich +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Distance perfectness of graphs
Discussiones Mathematicae Graph Theory, 1999 The author introduces a new generalization of perfect graphs. It turns out that the analogue of the weak perfect graph theorem is not true for this generalization. A subset \(Q\) of the vertex set \(V\) of a graph \(G\) is a \(k\)-distance clique in \(G\) if \(d_G(x,y)\leq k\) for any \(x,y\in Q\) and \(\langle Q\rangle_G\), the subgraph of \(G ...
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Discrete Mathematics, 1982 AbstractThe boolean distance between two points x and y of a connected graph G is defined as the set of all points on all paths joining x and y in G (Ø if x = y). It is determined in terms of the block-cutpoint graph of G, and shown to satisfy the triangle inequality b(x,y)⊆ b(x, z)∪b(z,y). We denote by B(G) the collection of distinct boolean distances
Frank Harary +3 more
openaire +3 more sources