Results 81 to 90 of about 1,232,284 (259)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

On Subgraphs in Distance-Regular Graphs [PDF]

open access: yesJournal of Algebraic Combinatorics, 1992
A graph is distance-regular when it is simple and for any two vertices at distance \(j\), the numbers of vertices adjacent to one and at distance \(j- 1\) (resp. \(j\) and \(j+1)\) of the other are constant (depending on \(j\) only). First some necessary conditions are derived for distance- regularity of the subgraph of the geodesics joining two ...
openaire   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

On the distance eigenvalues of Cayley graphs

open access: yesپژوهش‌های ریاضی, 2022
In this paper, graphs are undirected and loop-free and groups are finite. By Cn, Kn and Km,n we mean the cycle graph with n vertices, the complete graph with n vertices and the complete bipartite graph with parts size m and n, respectively.
Majid Arezoomand
doaj  

Structural Relationship of Isomorphic Graph and its Mapping to Hamming Distance [PDF]

open access: yesEPJ Web of Conferences
Mapping graph isomorphism to Hamming distance enables a simple yet effective approach to quantifying structural similarity. By encoding graphs as binary adjacency vectors—flattened from the upper triangle of the adjacency matrix—structural comparisons ...
Tiwari Monika   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

On the connectivity of $k$-distance graphs

open access: yesElectronic Journal of Graph Theory and Applications, 2017
For any $k \in \mathbb{N}$, the $k-$distance graph $D^{k}G$ has the same vertex set of $G$, and two vertices of $D^{k}G$ are adjacent if they are exactly distance $k$ apart in the original graph $G$. In this paper, we consider the connectivity of $D^{k}G$
Omid Khormali
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri   +7 more
wiley   +1 more source

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