Results 61 to 70 of about 114,934,093 (299)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Distance distribution in configuration-model networks [PDF]
Physical Review E, 2016 28 pages, 7 figures. Accepted for publication in Phys.
Nitzan, Mor +3 more
openaire +4 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Epidemics, 2020 Outbreaks of a plant disease in a landscape can be meaningfully modelled using networks with nodes representing individual crop-fields, and edges representing potential infection pathways between them.
Giovanni Strona +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Distance Oracles for Time-Dependent Networks [PDF]
Algorithmica, 2014 We present the first approximate distance oracle for sparse directed networks with time-dependent arc-travel-times determined by continuous, piecewise linear, positive functions possessing the FIFO property. Our approach precomputes $(1+ε)-$approximate distance summaries from selected landmark vertices to all other vertices in the network.
Spyros C. Kontogiannis +1 more
openaire +4 more sources
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Distance Transformation for Network Design Problems [PDF]
SIAM Journal on Optimization, 2019 Summary: We propose a new generic way to construct extended formulations for a large class of network design problems with given connectivity requirements. The approach is based on a graph transformation that maps any graph into a layered graph according to a given distance function.
Ali Ridha Mahjoub +3 more
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Distance-Based Routing Strategy for Traffic Transport in Spatial Networks
Advances in Mathematical Physics, 2013 It is well known that routing strategies based on global topological information is not a good choice for the enhancement of traffic throughput in large-scale networks due to the heavy communication cost.
Wei Huang +3 more
doaj +1 more source