Results 81 to 90 of about 2,130,896 (179)

Discovery of Potent EGFR Inhibitors for Del19 and L858R/T790M Mutants Through Structure‐Based Virtual Screening and Biological Evaluation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
XJ2‐2 overcomes NSCLC by blocking EGFR‑driven AKT/ERK cascades. ABSTRACT Epidermal growth factor receptor (EGFR) mutation‐mediated drug resistance represents a major clinical challenge in the treatment of non‐small cell lung cancer (NSCLC). In this study, the lead compound XJ2‐2 was identified through structure‐based virtual screening.
Ting Xu, Yuchen Zhao, Mengfei Chen, Lijuan Zuo, Hanshuang Cai, Yuguo Liu, Chuanfeng Liu, Jing Shi   +7 more
wiley   +1 more source

SARD1 and CBP60g redundantly regulate N‐hydroxypipecolic acid‐ and salicylic acid‐dependent systemic immunity but are dispensable for the activation of indolic defense metabolism

The Plant Journal, Volume 127, Issue 6, September 2026.
SUMMARY We investigated the roles of the cognate, redundantly acting transcription factors SARD1 and CPB60g in the metabolic reprogramming of leaves of Arabidopsis thaliana suffering from bacterial infection or UV light exposure. Comprehensive metabolite analyses reveal that SARD1/CBP60g exert distinct influences on major stress‐inducible metabolic ...
Mona Perrar, Marlene Gross, Patrick Petzsch, Karl Köhrer, Jürgen Zeier   +4 more
wiley   +1 more source

Spatial Distribution and Bioprospecting of Phytopathogenic Fungi on Amaranthus for Biological Control in Brazil

Weed Research, Volume 66, Issue 5, September/October 2026.
ABSTRACT The genus Amaranthus comprises approximately 70 species with a global distribution, particularly in tropical and subtropical regions. In Brazil, Amaranthus hybridus is a highly harmful weed characterised by aggressive ecophysiology, producing more than 250 000 viable seeds per plant and forming extensive soil seed banks.
Werik P. Dias, Adryelle A. Sousa, Lucas H. V. V. Carvalho, Mike S. J. Ferreira, André L. Firmino, Bruno S. Vieira   +5 more
wiley   +1 more source

The Magic lantern.

, 1985
Mode of access: Internet.Reprint. Orginally published weekly: Philadelphia : Benerman & Wilson. Vol. 1, no. 1 (Sept. 1874)-v. 1, no. 8 (Apr. 1875) issued as Vol. 7, no.
Magic Lantern Society of the United States and Canada.
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Systematics of Marmosa Subgenus Micoureus With Emphasis in ‘rapposa’ Group (Didelphidae, Marmosini): Geographic Variation and Revalidation of M. budini

Zoologica Scripta, Volume 55, Issue 5, Page 681-692, September 2026.
ABSTRACT Micoureus is the most species‐rich subgenus within the genus Marmosa. Conflicting arrangements regarding the number of species comprising this subgenus have been proposed and the validity of M. budini has been debated. Here, we used an approach integrating genetic and morphological data were conducted to reanalyze the ‘rapposa’ group ...
Maria Clara Santos Ribeiro, Aldo Caccavo, Joyce Rodrigues do Prado, Cibele Rodrigues Bonvicino   +3 more
wiley   +1 more source

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe, Ahmet Buğra Aksel, Ezgi Pehlivanlar Yavrucu, Hilal Zıvalı, Begüm Nurpelin Sağlık Özkan, İnci Selin Doğan   +5 more
wiley   +1 more source

Investigating the Binding Mode of a Naphthol‐Based Inhibitor Targeting SARS‐CoV‐2 Main Protease

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A highly integrated workflow combining various computational, biophysical, and biochemical methods guides the discovery and characterization of an original naphthol‐based scaffold with inhibitory activity against the main protease of SARS‐CoV‐2 and demonstrates the efficiency of a sophisticated, open‐access consensus ranking protocol for virtual ...
Ifigeneia Akrani, Haifa El Kilani, Franck Touret, Sophia Kouvali, Veronika Gourni, Aggeliki Tsoka, Joulia K. Tsetis, Constantinos Vorgias, Rolf Hilgenfeld, Ioannis K. Kostakis, Vassilios Myrianthopoulos, Emmanuel Mikros   +11 more
wiley   +1 more source

Hamiltonian Strongly Regular Graphs [PDF]

We give a sufficient condition for a distance-regular graph to be Hamiltonian. In particular, the Petersen graph is the only connected non-Hamiltonian strongly regular graph on fewer than 99 vertices.Distance-regular graphs;Hamilton cycles JEL ...
Brouwer, A.E., Haemers, W.H.
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Accompanying slides for the MAGIC publication "Gamma-ray flaring activity of NGC 1275 in 2016-2017 measured by MAGIC"

, 2019
This work is focused on the radio galaxy NGC 1275, the central galaxy of the Perseus cluster. The source was part of a MAGIC monitoring program and showed a very strong flare the night between 31st of December 2016 and the 1st of January 2017.
MAGIC Collaboration, MAGIC Collaboration (6332954)   +1 more
core   +1 more source

Developments on Spectral Characterizations of Graphs [PDF]

In [E.R. van Dam and W.H. Haemers, Which graphs are determined by their spectrum?, Linear Algebra Appl. 373 (2003), 241-272] we gave a survey of answers to the question of which graphs are determined by the spectrum of some matrix associated to the graph.
Dam, E.R. van, Haemers, W.H.
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