Results 51 to 60 of about 601,789 (263)
A cospectral construction for the generalized distance matrix
Special MatricesThe generalized distance matrix of a graph is a matrix in which the (i,j)\left(i,j)th entry is a function, ff, of the distance between vertex ii and vertex jj.
Friesen Ori +5 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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The calculation of the distance to a nearby defective matrix [PDF]
Numerical Linear Algebra with Applications, 2013 SUMMARYThe distance of a matrix to a nearby defective matrix is an important classical problem in numerical linear algebra, as it determines how sensitive or ill‐conditioned an eigenvalue decomposition of a matrix is. The concept has been discussed throughout the history of numerical linear algebra, and the problem of computing the nearest defective ...
Richard O. Akinola +2 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Preserving privacy of spatial distances using randomized geometric surface calculations
Journal of Spatial Information ScienceThis paper introduces and evaluates a novel method for privacy-preserving distance computations. The method is based on randomized geometric surface calculations and replaces coordinates with contextual variables representing information about the ...
Jonas Klingwort, Sarah Redlich
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Современные информационные технологии и IT-образование, 2019 Bioinformatics has two important problems for the study of evolutionary processes: calculating the distance between DNA sequences and restoring a matrix of distances sequences of different genomes when not all initial elements are known. Due to the large
Mikhail E. Abramyan +2 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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Factoring distance matrix polynomials
Discrete Mathematics, 1993 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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