Results 51 to 60 of about 981,066 (245)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Distance scale calibration based on early-type binaries
EPJ Web of Conferences, 2017 Our main goal is to establish a firm empirical calibration of the surface brightness vs. (V-K) color relation for early type stars based on high quality spectroscopic and infrared observations of early-type detached eclipsing systems in the Large ...
Taormina Mónica +4 more
doaj +1 more source
Distance education perception scale for medical students: a validity and reliability study
BMC Medical Education, 2021 Background There are major changes in education strategies as higher education institutions urgently need to adopt distance education tools and practices due to the Covid-19 pandemic.
Güven Özkaya +2 more
doaj +1 more source
The Cosmic Distance Scale [PDF]
Symposium - International Astronomical Union, 1987 The zero-point of the extragalactic distance scale, defined by about two dozens of nearby, late-type galaxies, has remained nearly unchanged for the last decade, in spite of the advent of new techniques and great efforts. The distances are essentially tied to trigonometric parallax stars and hence independent of the Hyades modulus; they are consistent ...
openaire +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Estimating Hubble Constant with Gravitational Observations: A Concise Review
GalaxiesThe Hubble constant is of paramount importance in astrophysics and cosmology. A large number of methods have been developed with different electromagnetic probes to estimate its value.
Rosa Poggiani
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
BMC Medical Education, 2023 Background Ultrasound assessment of the airway recently integrates the point-of-care approach to patient evaluation since ultrasound measurements can predict a difficult laryngoscopy and tracheal intubation. Because ultrasonography is performer-dependent,
Sara Hora Gomes +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source