Results 61 to 70 of about 981,066 (245)
Astronomy & AstrophysicsType Ia supernovae (SNe Ia) provide the robustest means of measuring extragalactic distances. While increasing the number of SNe Ia observed in the optical has received most effort so far, near-infrared (NIR) observations remain scarce despite their ...
Phan Kim +15 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Ecologies of Scale in the Age of Satellites and Television
Media + Environment, 2023 A correction has been published: [Corrigendum: Ecologies of Scale in the Age of Satellites and Television](https://mediaenviron.org/article/94073-corrigendum-ecologies-of-scale-in-the-age-of-satellites-and-television?auth_token=7M_EXWnApMu8gX62KbWd ...
Amy Rust
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
SLANG EXPRESSION IN LITTLE MAN MOVIE BASED ON SOCIAL DIMENSION
Lingua: Jurnal Bahasa, Sastra dan Pengajarannya, 2018 This research aims to reveal the slang expression (slang words) uttered by some characters in Little Man movie. To analyze them, the writers use Holmes’ references about social scale which is classified into four scales.
Wiruma Titian Adi, Alfian Azmi
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Scaling distances on finitely ramified fractals [PDF]
Kyoto Journal of Mathematics, 2017 In previous papers by A. Kameyama and by J. Kigami distances on fractals have been discussed having two different but similar properties. One property is that the maps defining the fractal are Lipschitz of prescribed constants less than 1, the other is that the diameters of the copies of the fractal are asymptotic to prescribed scaling factors. In this
openaire +5 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Development and reliability and validity test of patients' power distance scale
Huli yanjiu, 2022 ObjectiveTo develop the patients' power distance scale，and to test its reliability and validity.MethodsThe "power distance" dimension of cultural dimension theory was taken as the theoretical framework.The patients' power distance scale was developed ...
WANG Yinyu +3 more
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