Results 91 to 100 of about 113,608 (319)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

APPLICATION OF MODEL PREDICTIVE CONTROL (MPC) TUNING STRATEGY IN MULTIVARIABLE CONTROL OF DISTILLATION COLUMN [PDF]

, 2007
A model predictive control strategy is proposed for multivariable nonlinear control problem in a distillation column. The aim is to provide a solution to nonlinear control problem that is favorable in terms of industrial implementation.
Wahid, A., Ahmad, A., A. Wahid, A. Ahmad
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

New column configurations for pressure swing batch distillation I. Feasibility Studies [PDF]

, 2007
The feasibility of the pressure swing distillation in different batch column configurations is investigated. The method is based on the assumption of maximal separation. Besides studying the well known batch configurations (rectifier, stripper, middle
Modla, Gábor
core  

Behaviour Distillation

CoRR
Dataset distillation aims to condense large datasets into a small number of synthetic examples that can be used as drop-in replacements when training new models. It has applications to interpretability, neural architecture search, privacy, and continual learning. Despite strong successes in supervised domains, such methods have not yet been extended to
Andrei Lupu, Chris Lu 0001, Jarek Liesen, Robert Tjarko Lange, Jakob N. Foerster   +4 more
openaire   +3 more sources

Efficient Separation of Isoamyl Alcohol from Fusel Oil Using Non-Polar Solvent and Hybrid Decanter–Distillation Process

Applied Sciences
Fusel oil is a fermentation by-product composed of a complex mixture of alcohols (ethanol, isoamyl, propanol, and butanol isomers) and water. The primary challenges lie in water separation and the recovery of the valuable component, isoamyl alcohol.
Mihaela Neagu, Diana-Luciana Cursaru, Alexey Missyurin, Octavian Goian   +3 more
doaj   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

BitNet Distillation

CoRR
In this paper, we present BitNet Distillation (BitDistill), a lightweight pipeline that fine-tunes off-the-shelf full-precision LLMs (e.g., Qwen) into 1.58-bit precision (i.e., ternary weights {-1, 0, 1}) for specific downstream tasks, achieving strong task-specific performance with minimal computational cost.
Xun Wu, Shaohan Huang, Wenhui Wang 0003, Ting Song, Li Dong 0004, Yan Xia 0005, Furu Wei   +6 more
openaire   +2 more sources

PROSPECTS OF APPLYING HEAT PUMPS UPON CARRYING OUT COMBINED MASS TRANSFER PROCESSES

Тонкие химические технологии, 2018
The prospects of using heat pumps for the separation of mixtures by combination of different mass transfer processes are considered, which is associated with the supply and removal of thermal energy.
G. A. Nosov, M. V. Mikhailov
doaj   +1 more source