Results 71 to 80 of about 627,001 (273)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Detection of TCP targeted high bandwidth attacks using self-similarity
Journal of King Saud University: Computer and Information Sciences, 2020 In this paper the authors have tried to measure the impact of different variants of pulsating distributed denial of service attacks on the self-similar nature of the network traffic and to see if the variation in the H index could be used for ...
Gagandeep Kaur, Vikas Saxena, J.P. Gupta
doaj +1 more source
An econometric analysis of tourism in Spain: implications for the sectoral study of exports and some economic policy considerations [PDF]
, 1992 This paper deals with the construction of econometric models to explain the external demand for Spanish tourist services. The models include as explanatory economic variables a tourist income index and two real exchange rate indices, one with respect to ...
Espasa, Antoni +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
BLEI: Research on a Novel Remote Sensing Bare Land Extraction Index
Remote SensingBare land, as a significant land cover type on the Earth’s surface, plays a crucial role in supporting land-use planning, urban management, and ecological environmental research through the investigation of its spatial distribution.
Chaokang He +4 more
doaj +1 more source
Assessment of trends in Russian regions social sustainability over the years 2001-2012
Наука. Инновации. Технологии, 2022 Some methods of social sustainability was elaborated by Russian and inter-national scientists, but there is still no researches of its dynamics with reference to Russian regions.
Vladimir Sergeyevich Tikunov +1 more
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Distinguishing number and distinguishing index of strong product of two graphs
, 2017 The distinguishing number (index) $D(G)$ ($D'(G)$) of a graph $G$ is the least integer $d$ such that $G$ has an vertex labeling (edge labeling) with $d$ labels that is preserved only by a trivial automorphism. The strong product $G\boxtimes H$ of two graphs $G$ and $H$ is the graph with vertex set $V (G)\times V (H)$ and edge set $\{\{(x_1, x_2), (y_1,
Alikhani, Saeid, Soltani, Samaneh
openaire +3 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Degree-based fuzzy indices analysis of two snake graphs
Ain Shams Engineering JournalFuzzy topological indices hold significant importance due to their applications in various real-world networks such as social networking, telecommunications, Engineering, Chemical graph theory, computational biochemistry, statistical physics etc. Through
Syed Shahzaib +2 more
doaj +1 more source