Results 81 to 90 of about 402,994 (257)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Some Equal Degree Graph Edge Chromatic Number
MATEC Web of Conferences, 2016 Let G(V, E) be a simple graph and k is a positive integer, if it exists a mapping of f, and satisfied with f(e1)≠6 = f(e2) for two incident edges e1,e2∉E(G), f(e1)≠6=f(e2), then f is called the k-proper-edge coloring of G(k-PEC for short).
Liu Jun +4 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Acta Societatis Botanicorum Poloniae, 2015 The author presents a new conception of distinguishing taxonomic units, while taking into .account a precise class of characters, It is shown on the taxonomy of species of Delia Dum., Spergula L., and Spergularia Presl., growning in Poland and based on ...
Tadeusz Kowal
doaj +1 more source
Distinguishing number and distinguishing index of join of two graphs
, 2016 12 pages, 2 ...
Alikhani, Saeid, Soltani, Samaneh
openaire +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Distinguishing number and distinguishing index of graphs from primary subgraphs
, 2016 The distinguishing number (index) $D(G)$ ($D'(G)$) of a graph $G$ is the least integer $d$ such that $G$ has an vertex labeling (edge labeling) with $d$ labels that is preserved only by a trivial automorphism. Let $G$ be a connected graph constructed from pairwise disjoint connected graphs $G_1,\ldots ,G_k$ by selecting a vertex of $G_1$, a vertex of ...
Soltani, Samaneh, Alikhani, Saeid
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
General Vertex-Distinguishing Total Colorings of Complete Bipartite Graphs
MathematicsLet G be a simple graph. A general total coloring f of G refers to a coloring of the vertices and edges of G. Let C(x) be the set of colors of vertex x and edges incident with x under f. For a general total coloring f of G in which k colors are available,
Xiang’en Chen, Ting Li
doaj +1 more source
Neighbor Sum Distinguishing Total Choosability of IC-Planar Graphs
Discussiones Mathematicae Graph Theory, 2020 Two distinct crossings are independent if the end-vertices of the crossed pair of edges are mutually different. If a graph G has a drawing in the plane such that every two crossings are independent, then we call G a plane graph with independent crossings
Song Wen-Yao +2 more
doaj +1 more source