Results 191 to 200 of about 2,286,559 (387)

Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.

open access: yesNew England Journal of Medicine, 1998
M. Amato   +11 more
semanticscholar   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

open access: yesAdvanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng   +7 more
wiley   +1 more source

Distress tolerance to auditory feedback and functional connectivity with the auditory cortex

open access: green, 2018
Merideth A. Addicott   +3 more
openalex   +2 more sources

Do private equity owners increase risk of financial distress and bankruptcy? [PDF]

open access: yes
There is some controversy on the key sources of success in the private equity model and on how this business model affects the portfolio companies.
Borell, Mariela, Tykvová, Tereza
core  

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang   +12 more
wiley   +1 more source

Distress Management [PDF]

open access: yesJournal of the National Comprehensive Cancer Network, 2010
Jimmie C, Holland   +22 more
openaire   +2 more sources

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

open access: yesAdvanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee   +6 more
wiley   +1 more source

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