Results 91 to 100 of about 155,602 (285)

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

SOS Detection: Distress Signal Recognition

International Research Journal on Advanced Engineering Hub (IRJAEH)
In emergency situations where individuals cannot verbally call for help, there is a critical need for a reliable and efficient non-verbal communication system. This project proposes a real-time SOS gesture recognition solution using advanced computer vision techniques to address this need.
null Mukesh N, null Nithis Bangaru B, null Vignesh Kumaran A, null Mrs.S.Athilakshmi   +3 more
openaire   +1 more source

Surface Classification for Road Distress Detection System Enhancement [PDF]

, 2012
This paper presents a vision-based road surface classification in the context of infrastructure inspection and maintenance, proposed as stage for improving the performance of a distress detection system. High resolution road images are processed to distinguish among surfaces arranged according to the different materials used to build roads and their ...
Miguel Gavilán, David Balcones, Miguel Ángel Sotelo, David Fernández Llorca, Oscar Marcos Martín, Carlos Fernández 0001, Iván García Daza, Raúl Quintero   +7 more
openaire   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

A critical review on pavement distress detection using images and point clouds from visual features to geometric modeling

Journal of Road Engineering
Pavement distress detection plays a pivotal role in ensuring roadway safety, serviceability, and cost-effective infrastructure management. With rapid advancements in intelligent transportation systems, computer vision, and sensing technologies, non ...
Jiayv Jing, Xu Yang, Hang Cheng, Xu Feng, Hao Zheng, Ioannis Brilakis, Jiamei Liu   +6 more
doaj   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

A 2D-approach towards the detection of distress using Fuzzy K-Nearest Neighbor [PDF]

, 2019
Paper presented at the 5th Strathmore International Mathematics Conference (SIMC 2019), 12 - 16 August 2019, Strathmore University, Nairobi, KenyaThis research focuses on a novel approach of distress detection referred to as the 2D approach, using the ...
Machanje, Daniel, Orero, Joseph
core  

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

A Review of the Literature on Early Warning Systems for Banking Crises [PDF]

This paper presents a review of alternative methodologies for early detection of banking distress. The methodologies proposed are aimed to the early identification of financial distress for countries without an important recent history of bank failure ...
Alejandro Gaytán, Christian A. Johnson
core