Results 81 to 90 of about 1,127,182 (258)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A Data Compression Algorithm for Wireless Sensor Networks Based on an Optimal Order Estimation Model and Distributed Coding

Sensors, 2010
In many wireless sensor network applications, the possibility of exceptions occurring is relatively small, so in a normal situation, data obtained at sequential time points by the same node are time correlated, while, spatial correlation may exist in ...
Sheng-Qiang Li, Peng Jiang
doaj   +1 more source

Distributed-Order Fractional Graph Operating Network

Advances in Neural Information Processing Systems 37
We introduce the Distributed-order fRActional Graph Operating Network (DRAGON), a novel continuous Graph Neural Network (GNN) framework that incorporates distributed-order fractional calculus. Unlike traditional continuous GNNs that utilize integer-order or single fractional-order differential equations, DRAGON uses a learnable probability distribution
Zhao, Kai, Li, Xuhao, Kang, Qiyu, Ji, Feng, Ding, Qinxu, Zhao, Yanan, Liang, Wenfei, Tay, Wee Peng   +7 more
openaire   +2 more sources

Numerical approximation of distributed order reaction–diffusion equations

Journal of Computational and Applied Mathematics, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rebelo, Magda, Morgado, Maria Luísa
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Collaborative security assessment of cloud-edge-device distributed systems based on order parameters

网络与信息安全学报
Distributed computing systems based on cloud-edge-device have been successfully serving thousands of applications and have become mainstream, characterized by a wide audience, high user experience requirements, and high security expectations. However, in
FAN Qigang, JIANG Zhongyuan, LI Xinghua, MA Jianfeng   +3 more
doaj   +3 more sources

Distributed Optimization Control for the System with Second-Order Dynamic

Mathematics
No matter whether with constraint or without constraint, most of the research about distributed optimization is studied for the kind of quadratic performance criteria that does not have an integrator; these optimization problems only concern the state ...
Yueqing Wang, Hao Zhang, Zhi Li
doaj   +1 more source

Stability Analysis of Linear Time‐Invariant Distributed‐Order Systems

Asian Journal of Control, 2012
AbstractThe bounded‐input bounded‐output stability condition of a linear time invariant (LTI) distributed‐order system over integral interval (0,1) has been established for the first time. Two cases about weighting function of the distributed order are investigated, and sufficient and necessary conditions of stability for these two types of distributed‐
Jiao, Zhuang, Chen, YangQuan, Zhong, Yisheng   +2 more
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source