Results 31 to 40 of about 8,009 (192)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Scalable Microservice Architecture for Autonomous IoT Systems in Smart Transportation: Integration of Edge Computing, Real-Time Processing, and Security

IEEE Access
The rapid proliferation of Internet of Things (IoT) devices in smart transportation systems has introduced unprecedented challenges in managing high-volume, high-velocity data streams. Maintaining real-time responsiveness and security in these systems is
Mohammed A. Alzahrani, Emad Y. Albassam
doaj   +1 more source

Bio-inspired Agentic Self-healing Framework for Resilient Distributed Computing Continuum Systems

CoRR
Human biological systems sustain life through extraordinary resilience, continually detecting damage, orchestrating targeted responses, and restoring function through self-healing. Inspired by these capabilities, this paper introduces ReCiSt, a bio-inspired agentic self-healing framework designed to achieve resilience in Distributed Computing Continuum
Saleh, Alaa, Donta, Praveen Kumar, Morabito, Roberto, Tarkoma, Sasu, Lindgren, Anders, Zhang, Qiyang, Dustdar, Schahram, Pirttikangas, Susanna, Lovén, Lauri   +8 more
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Softwarized Edge Intelligence for Advanced IIoT Ecosystems: A Data-Driven Architecture Across the Cloud/Edge Continuum

Applied Sciences
The evolution of Industrial Internet of Things (IIoT) systems demands flexible and intelligent architectures capable of addressing low-latency requirements, real-time analytics, and adaptive resource management.
David Carrascal, Javier Díaz-Fuentes, Nicolas Manso, Diego Lopez-Pajares, Elisa Rojas, Marco Savi, Jose M. Arco   +6 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Innovative Horizons in IoT and Cloud Continuum: Enhancing Data Processing and Advanced Analytical Solutions

Journal of Computer Networks and Communications
The convergence of the Internet of Things (IoT) with cloud, edge, and fog computing has catalyzed a transformative shift in data processing and real-time analytics across multiple sectors.
Alaa Kamal Yousif Dafhalla, Hiba Mohanad Isam, Shireen Zangana, Asma Ibrahim Gamar Eldeen, Tijjani Adam   +4 more
doaj   +1 more source