Results 91 to 100 of about 6,540 (265)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Fractional derivative in continuous-time Markov processes and applications to epidemics in networks

Physical Review Research
Continuous-time Markov processes are governed by the Chapman-Kolmogorov differential equation. We show that replacing the standard time derivative of the governing equation with a Caputo fractional derivative of order ...
Matteo D'Alessandro, Piet Van Mieghem
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

An Analysis of Controllability Criteria for Higher-Order Caputo Fractional Differential Systems With State and Control Delays

International Journal of Differential Equations
The present study investigates the controllability problems for higher-order semilinear fractional differential systems (HOSLFDSs) with state and control delays in the context of the Caputo fractional derivative.
Anjapuli Panneer Selvam, Venkatesan Govindaraj, Raaid Alubady, Sina Etemad   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Generalized Fourier transforms applied to fractional derivatives and Quantum Statistics Distributions

, 2019
In the present article the author extends the Fourier transform to a more general class of functions; First to power-law functions with integer and half-integer exponents then to the widely used quantum statistics function (Fermi-Dirac and Bose-Einstein-distributions).
openaire   +2 more sources

Dağılımlı mertebeden kesirli türev ve integral = Distributed order fractional derivative and integral /

, 2022
In this thesis, which is prepared as a Master of Science thesis, a numerical method has been researched to find approximate solutions of a distributed order differential equation, which includes the concepts of distributional order derivative and integral.
Tekeli, Fatma, 1992- author 227650, Yakıt Ongun, Mevlüde, 1973- 15188 thesis advisor, Süleyman Demirel Üniversitesi. Fen Bilimleri Enstitüsü. Matematik Anabilim Dalı. 10117 issuing body   +2 more
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

An accurate collocation method for distributed order time fractional nonlinear diffusion wave equation with error analysis

Results in Applied Mathematics
The distributed-order fractional nonlinear diffusion-wave problem is a mathematical model that combines the concepts of fractional calculus and nonlinear diffusion-wave equations.
M. Taghipour, H. Aminikhah
doaj   +1 more source