Results 111 to 120 of about 5,000,649 (308)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Flexible Resolution of Authorisation Conflicts in Distributed Systems [PDF]

, 2008
Flexible Resolution of Authorisation Conflicts in Distributed ...
Giovanni Russello, Dong, Changyu, Changyu Dong, Naranker Dulay, Russello, Giovanni, Russello, G., N. Dulay, C. Dong, Dong, C., Dulay, N., Dulay, Naranker   +10 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Performance Evaluation of Fuel Cell and Microturbine as Distributed Generators in a Microgrid [PDF]

, 2009
This paper presents dynamic models of distributed generators (DG) and investigates dynamic behaviour of the DG units within a microgrid system. The DG units include micro turbine, fuel cell and the electronically interfaced sources.
Mohamed , Azah, Nizam , Muhammad, Salam , A.A.   +2 more
core  

Distributed generation powered by smart grids

Dyna
Smart grids are conceived as a system to optimally manage the set of means that are part of the electricity grid to achieve adequate performance in the distributed generation system in the supply of quality electricity.
Alcira Magdalena Vélez-Quiroz, Miriam Lourdes Filgueiras-Sainz de Rozas, Miriam Vilaragut-Llanes, María Rodríguez-Gámez, Gino Joaquín Mieles-Mieles, Efrain Pérez-Vega   +5 more
doaj   +1 more source

A new algorithm for allocating multiple distributed generation units based on load centroid concept

Alexandria Engineering Journal, 2013
Allocation of distributed generation (DG) units is commonly formulated as a constrained nonlinear optimization problem solved by complex iterative mathematical or heuristic techniques.
A. Elmitwally
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The economics of distributed energy generation : a literature review [PDF]

, 2014
The UK electricity system is likely to face dramatic technical and institutional changes in the near future. Current UK energy policy focuses on the need for a clean, affordable and secure energy supply.
McGregor, Peter, Allan, Grant, McGregor, Peter G, Gilmartin, Michelle, Eromenko, Igor, Kockar, Ivana   +5 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source