Results 61 to 70 of about 27,922 (264)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

On the Generalized Lognormal Distribution [PDF]

Journal of Probability and Statistics, 2013
This paper introduces, investigates, and discusses the -order generalized lognormal distribution (-GLD). Under certain values of the extra shape parameter , the usual lognormal, log-Laplace, and log-uniform distribution, are obtained, as well as the degenerate Dirac distribution. The shape of all the members of the -GLD family is extensively discussed.
Thomas L. Toulias, Christos P. Kitsos
openaire   +3 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

The Impact of Power Source Performance Decrease in a PV/WT/FC Hybrid Power Generation System on the Result of a Multi-Criteria Analysis of Load Distribution

Energies, 2019
The article presents a mathematical model designed for scheduling cooperation between Hybrid Power Generation System HPGS and an electricity system viewed from a multifaceted perspective.
Bartosz Ceran, Agata Orłowska
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

The generalized distributive law [PDF]

IEEE Transactions on Information Theory, 2000
Summary: In this semitutorial paper we discuss a general message passing algorithm, which we call the generalized distributive law (GDL). The GDL is a synthesis of the work of many authors in the information theory, digital communications, signal processing, statistics, and artificial intelligence communities.
Aji, Srinivas M., McEliece, Robert J.
openaire   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

A Fast Fault Detection Scheme for Power Converters In Distributed Generation Systems

Eletrônica de Potência, 2012
In this paper, a fault detection algorithm based on voltage disturbances is proposed and analyzed. This method observes the voltage characteristics instead of the current amplitude, that is the most common approach in power distribution electrical ...
Gustavo M. S. Azevedo, Marcelo C. Cavalcanti, Francisco A. S. Neves, Fabricio Bradaschia   +3 more
doaj   +1 more source