Results 81 to 90 of about 247,233 (313)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
A sustainable query processing method in distributed stream environment [PDF]
, 2007 センサーなどから得られるストリームデータの増加により，それらに対する継続的な監視要求が高まっている．監視要求を実現するシステムでは，長期に渡って到着データの監視処理を続ける必要があり，障害によるシステム停止は極めて影響が大きい．我々の研究グループでは，高信頼なストリーム処理実現のため，仮想マシン技術を組合せた持続型ストリーム処理環境の構築を行っている．本環境では，仮想マシン上で問合せ処理を行い，仮想マシンの実行状態を定期的に別のマシンへ配布することで，1 台が停止した場合にも ...
Kitagawa Hiroyuki +3 more
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Peer-based query rewriting in SPARQL for semantic integration of linked data [PDF]
, 2015 In this proposal we address the problem of ontology-based SPARQL query answering over distributed Linked Data sources, where the ontology is given by conjunctive mappings between the source schemas in a peer-to-peer fashion and by equality constraints ...
Dimartino, Mirko
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Evaluation of DFTDS algorithm for distributed data warehouse
Egyptian Informatics Journal, 2014 The distributed data warehouse is mainly based on how the data are being processed and distinguish between dynamic and physically distributed systems.
S. Krishnaveni, M. Hemalatha
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The application of artificial intelligence techniques to large distributed networks [PDF]
Data accessibility and transfer of information, including the land resources information system pilot, are structured as large computer information networks.
Dubyah, R., Smith, T. R., Star, J. L.
core +1 more source