Results 81 to 90 of about 2,422 (292)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

InSAR Greece with Parallelized Persistent Scatterer Interferometry: A National Ground Motion Service for Big Copernicus Sentinel-1 Data

Remote Sensing, 2020
Advances in synthetic aperture radar (SAR) interferometry have enabled the seamless monitoring of the Earth’s crust deformation. The dense archive of the Sentinel-1 Copernicus mission provides unprecedented spatial and temporal coverage; however, time ...
Ioannis Papoutsis, Charalampos Kontoes, Stavroula Alatza, Alexis Apostolakis, Constantinos Loupasakis   +4 more
doaj   +1 more source

Bridging Loss-of-Lock in InSAR Time Series of Distributed Scatterers

, 2023
We introduce the term loss-of-lock to describe a specific form of coherence loss that results in the breakage of a synthetic aperture radar interferometric (InSAR) time series.
Hanssen, R.F. (author), van Leijen, F.J. (author), Conroy, Philip (author), van Diepen, S.A.N. (author)   +3 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Time-resolved analytical model for Raman scattering in a diffusive medium [PDF]

, 2017
In this work an analytical model for the time-resolved signal emitted by a uniformly distributed Raman scatterer in a diffusive parallelepiped is derived and validated with Monte Carlo (MC ...
Konugolu Venkata Sekar, Sanathana, Andrea Farina, Farina, Andrea, Martelli, Fabrizio, Antonio Pifferi, Binzoni, Tiziano, Pifferi, Antonio, Fabrizio Martelli, Tiziano Binzoni, Sanathana Konugolu Venkata Sekar   +9 more
core   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Ultrasonic Nakagami Imaging: A Strategy to Visualize the Scatterer Properties of Benign and Malignant Breast Tumors

, 2011
Previous studies have demonstrated the usefulness of the Nakagami parameter in characterizing breast tumors by ultrasound. However, physicians or radiologists may need imaging tools in a clinical setting to visually identify the properties of breast ...
崔博翔;葉秩光;廖尹吟;張建成;郭文宏;張金堅;陳炯年, TSUI, PO-HSIANG;YEH, CHIH-KUANG;LIAO, YIN-YIN;CHANG, CHIEN-CHENG;KUO, WEN-HONG;CHANG, KING-JEN;CHEN, CHIUNG-NIEN   +1 more
core   +1 more source