An instance‐level, model‐agnostic explanation of class differentiation is introduced through SHAP‐LCD, linking probability shifts to feature‐wise Shapley contributions. The method operates on tabular and image data and is released in a fully reproducible implementation, offering a transparent way to examine, at each instance, why predictive models ...
Roxana M. Romero Luna +2 more
wiley +1 more source
Unraveling G‐Quadruplex and i‐Motif Coexistence Within a Double‐Stranded DNA
The relative thermodynamic profiles of G‐quadruplex (G4), i‐Motif (iM), and the duplex counterpart tune the simultaneous G4 and iM formation within a double‐stranded (ds) DNA. ABSTRACT DNA can transiently fold into variable arrangements, which are expected to exploit regulatory functions. Guanine‐rich sequences can fold into G‐quadruplexes (G4s), while
Davide Auricchio +7 more
wiley +2 more sources
Lost in aggregation? On the importance of local food price data for food poverty estimates
Abstract This paper explores within‐country variations in food price dynamics and food poverty estimates by employing local market price data and national consumer price index (CPI) data. Our results show that national CPI data may be useful for approximating national trends but they fail to detect and identify spatial variations in local trends, which
Stephan Dietrich +4 more
wiley +1 more source
Using a ketal‐protected glycerol derivative (solketal) as the oxidation substrate enables site‐selective electrooxidation that suppresses C–C cleavage on non‐noble catalysts. Highly alkaline conditions promote reactive solketal alkoxide formation, weaken the Cα─H bond to facilitate dehydrogenation, and buffer local acidification, enabling a record‐high
Jiamin Wang +6 more
wiley +2 more sources
Multimodality quantitative ultrasound envelope statistics imaging based support vector machines for characterizing tissue scatterer distribution patterns: Methods and application in detecting microwave-induced thermal lesions. [PDF]
Li S, Tsui PH, Wu W, Zhou Z, Wu S.
europepmc +1 more source
Can Machine Learning and PS-InSAR Reliably Stand in for Road Profilometric Surveys? [PDF]
Fiorentini N +3 more
europepmc +1 more source
Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim +13 more
wiley +1 more source
Iterative Synthesis of Pyrene–Coronene Molecular Graphene Nanoribbons
An iterative approach delivers a new family of undoped, cove‐edged graphene nanoribbons with lengths up to 9.1 nm that exhibit both molar absorptivity and fluorescence brightness values on the order of 105 M−1 cm−1 and an intrinsic charge‐carrier mobility of 475 ± 32 cm2 V−1 s−1.
Miguel A. Medel +6 more
wiley +2 more sources
Weather radar detection of planetary boundary layer and smoke layer top of peatland fire in Central Kalimantan, Indonesia. [PDF]
Rahman MA +7 more
europepmc +1 more source
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq +5 more
wiley +1 more source

