Results 91 to 100 of about 408,117 (264)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

A Population-Based Search Approach to Solve Continuous Distributed Constraint Optimization Problems

Applied Sciences
Distributed Constraint Optimization Problems (DCOPs) are an efficient framework widely used in multi-agent collaborative modeling. The traditional DCOP framework assumes that variables are discrete and constraint utilities are represented in tabular ...
Xin Liao, Khoi D. Hoang
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Universal power laws in two-dimensional diffusive search for randomly distributed targets

Physical Review Research
We consider a two-dimensional diffusional search of randomly distributed targets characterized by their density and size. We derive analytical expressions for the binding rates averaged over ensembles of randomly distributed targets and initial positions
Rawan M. Nowier, Nilaj Chakrabarty, Peter Jung   +2 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Optimizing competitive team synergy through compatibility-aware graph search in distributed platforms

Journal of Cloud Computing: Advances, Systems and Applications
In competitive sports and other role-based team activities, selecting a squad with strong mutual compatibility is critical for coordinated execution and overall performance.
Yanfeng Li, Xiaochun Yin, Kangrong Luo, Yihe Gai, Xuan Yang   +4 more
doaj   +1 more source

Distributed Event-Driven Bayesian Search for Multi-UAV Systems with Spatially Correlated Targets

Sensors
Rapid cooperative detection of stationary targets by multiple unmanned aerial vehicles (UAVs) is important in time-critical missions such as search and rescue.
Dunbiao Niu, Peng Yi, Yiguang Hong
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Efficient algorithms for string pattern matching to protect search content

网络与信息安全学报
Efficient algorithms for online string pattern matching have been deemed crucial for cloud database retrieval. However, the potential leaking of search content has been recognized as a threat to users' privacy. Existing string pattern matching algorithms
Jianxu WANG, Rui LI, Yin LI
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source