Results 121 to 130 of about 318,000 (315)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Storage Management as Means to cope with Exponential Information Growth

open access: yes, 2003
Brinkmann A, Meyer auf der Heide F, Salzwedel K, Scheideler C, Vodisek M, Rückert U. Storage Management as Means to cope with Exponential Information Growth. In: Proceedings of SSGRR 2003.
Vodisek, Mario   +5 more
core  

Location and Capacity Optimization of Distributed Energy Storage System in Peak-Shaving

open access: yes, 2020
The peak-valley characteristic of electrical load brings high cost in power supply coming from the adjustment of generation to maintain the balance between production and demand.
Chao Lu   +4 more
core   +1 more source

Green Electrode Processing Enabled by Fluoro‐Free Multifunctional Binders for Lithium‐Ion Batteries

open access: yesAdvanced Science
The eco‐friendly processing of conjugated polymer binder for lithium‐ion batteries demands improved polymer solubility by introducing functional moieties, while this strategy will concurrently sacrifice polymer conductivity.
Xiuyu Jin   +16 more
doaj   +1 more source

Phase transformation mechanism in lithium manganese nickel oxide revealed by single-crystal hard X-ray microscopy

open access: yesNature Communications, 2017
As an intercalation electrode material for lithium ion batteries, spinel LixMn1.5Ni0.5O4possesses a metastable nature during the electrochemical operation.
Saravanan Kuppan   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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