Results 81 to 90 of about 7,169 (217)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Virtual Synchronous Motor Based-Control of a Three-Phase Electric Vehicle Off-Board Charger for Providing Fast-Charging Service

Applied Sciences, 2018
This study introduces a three-phase virtual synchronous motor (VSM) control and its possible application for providing fast-charging service from off-board chargers of electric vehicles (EVs). The main circuit of the off-board charger consists of a three-
Xiangwu Yan, Jiajia Li, Bo Zhang, Zhonghao Jia, Yang Tian, Hui Zeng, Zhipeng Lv   +6 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Design and demonstration of a power flow balancing method for ring-type distribution networks based on rotary power flow controller

International Journal of Electrical Power & Energy Systems
To address issues such as local overloading of distribution feeders and reduced system reliability caused by heterogeneous network planning and unbalanced source–load allocation, this paper proposes a power-balancing method for flexible interconnection ...
Wenchao Cai, Weilin Wu, Baixue Liang, Chen Shao, Jiaoxin Jia, Xiangwu Yan   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Far-field coherent thermal emission from polaritonic resonance in individual anisotropic nanoribbons

Nature Communications, 2019
An approach to achieve and directly measure enhancement of the thermal emission in far-field is lacking. Here, a thermometry platform was devised to extract the thermal emissivity from anisotropic nanoribbons of polar dielectrics, allowing direct ...
Sunmi Shin, Mahmoud Elzouka, Ravi Prasher, Renkun Chen   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Green Electrode Processing Enabled by Fluoro‐Free Multifunctional Binders for Lithium‐Ion Batteries

Advanced Science
The eco‐friendly processing of conjugated polymer binder for lithium‐ion batteries demands improved polymer solubility by introducing functional moieties, while this strategy will concurrently sacrifice polymer conductivity.
Xiuyu Jin, Ziting Zhu, Qiusu Miao, Chen Fang, Di Huang, Raynald Giovine, Linfeng Chen, Chaochao Dun, Jeffrey J. Urban, Yanbao Fu, Defu Li, Katie Liu, Yunfei Wang, Tianyu Zhu, Chenhui Zhu, Wei Tong, Gao Liu   +16 more
doaj   +1 more source

Phase transformation mechanism in lithium manganese nickel oxide revealed by single-crystal hard X-ray microscopy

Nature Communications, 2017
As an intercalation electrode material for lithium ion batteries, spinel LixMn1.5Ni0.5O4possesses a metastable nature during the electrochemical operation.
Saravanan Kuppan, Yahong Xu, Yijin Liu, Guoying Chen   +3 more
doaj   +1 more source