Results 81 to 90 of about 3,429,435 (288)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Balancing latency and availability in geo-distributed cloud data stores [PDF]

, 2013
Modern web applications face stringent requirements along many dimensions including latency, scalability, and availability. In response, several geo-distributed cloud storage systems have emerged in recent years.
Tawarmalani, Mohit, P N, Shankaranarayanan, Sivakumar, Ashiwan, Rao, Sanjay   +3 more
core  

Cooperative control of virtual energy storage devices for energy regulation and rapid frequency support

Frontiers in Energy Research
Various controllable resources contribute to energy regulation and rapid support in the form of virtual energy storage (VES), which can significantly simplify control parameters and facilitate the evaluation of a microgrid’s economic and secure ...
Zheng Yang, Zheng Yang, Yi Wang, Jiahui Wei, Yabo Cao   +4 more
doaj   +1 more source

Layered-rocksalt intergrown cathode for high-capacity zero-strain battery operation

Nature Communications, 2021
The dependence on lithium-ion batteries leads to a pressing demand for advanced cathode materials. Here the authors report a new concept of layered-rocksalt intergrown structure that enables nearly zero-strain operation upon high-capacity cycling ...
Ning Li, Meiling Sun, Wang Hay Kan, Zengqing Zhuo, Sooyeon Hwang, Sara E. Renfrew, Maxim Avdeev, Ashfia Huq, Bryan D. McCloskey, Dong Su, Wanli Yang, Wei Tong   +11 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inverse design of photonic surfaces via multi fidelity ensemble framework and femtosecond laser processing

npj Computational Materials
We demonstrate a multi-fidelity (MF) machine learning ensemble framework for the inverse design of photonic surfaces, trained on a dataset of 11,759 samples that we fabricate using high throughput femtosecond laser processing. The MF ensemble combines an
Luka Grbčić, Minok Park, Mahmoud Elzouka, Ravi Prasher, Juliane Müller, Costas P. Grigoropoulos, Sean D. Lubner, Vassilia Zorba, Wibe Albert de Jong   +8 more
doaj   +1 more source

Performance of the battery energy storage systems based on cascaded H-bridge multilevel converter

The Journal of Engineering, 2019
The battery energy storage system (BESS) based on the cascaded multilevel converter, that consists of cascaded H-bridge converter, is one of the most promising and interesting options, which is taken to compensate the instability of electric power grid ...
Abuzaid Saeed Gadalla, Xiangwu Yan, Hashim Hasabelrasul   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Distributed storage manager system for synchronized and scalable AV services across networks [PDF]

, 2011
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi Publishing CorporationThis paper provides an innovative solution, namely, the distributed storage manager that opens a new path for highly ...
Muhammad Ali Farmer, Waheed, A, Cosmas, J, Sun, FX, John Cosmas, Frank X. Sun, Abdul Waheed, Farmer, MA   +7 more
core   +1 more source