Results 101 to 110 of about 20,139,538 (294)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Generator Maintenance Scheduling Method Using Transformation of Mixed Integer Polynomial Programming in a Power System Incorporating Demand Response

open access: yesEnergies, 2019
Periodic preventive maintenance of generators is required to maintain the reliable operation of a power system. However, generators under maintenance cannot supply electrical energy to the power system; therefore, it is important to determine an optimal ...
Hyung-Chul Jo   +2 more
doaj   +1 more source

New-Onset Cancer Cases in FDA's Sentinel System: A Large Distributed System of US Electronic Healthcare Data. [PDF]

open access: yesCancer Epidemiol Biomarkers Prev, 2022
Haug NR   +5 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Authorship Gender Recognition of Source Code Based on Multiple Mixed Features [PDF]

open access: yesJisuanji kexue
With the development of the Internet,network security is increasingly concerned,and cracking down on malicious code authors is an important part of it.At present,author identification through malicious code writing style has achieved remarkable results ...
LIU Hongle, CHEN Juan, FU Cai, HAN Lansheng, GUO Xiaowei, JIANG shuai
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

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