Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
H2O : An autonomic, resource-aware distributed database system
, 2010 This paper presents the design of an autonomic, resource-aware distributed database which enables data to be backed up and shared without complex manual administration.
Macdonald, Angus +2 more
core
As power generation systems with increasingly higher capacities are interconnected with distribution networks, a pressing need arises for a thorough analysis of their integration and the subsequent impacts on medium-voltage lines.
Daniel Guillén-López +3 more
core +1 more source
Network characteristics emerging from agent interactions in balanced distributed system. [PDF]
Comput Soc Netw, 2015 Salman MA, Bertelle C, Sanlaville E.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Formal modeling of a causal consistent distributed system and verification of its history <i>via</i> model checking using colored Petri net. [PDF]
PeerJ Comput SciAlsaegg KAM +2 more
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
The paper describes the analysis of the problems of using microservice architecture in distributed systems. Emphasis is placed on flexibility in the choice of technologies, scalability and organization of teams working on given microservices, technical ...
Glybovets, A.M. +2 more
core
Teamwork without talking: distributed system estimates maintain approximately centralized control of smart urban drainage systems during communications outages. [PDF]
Water Res XDantzer TA, Kerkez B.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source