Results 61 to 70 of about 430,667 (336)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

State of the art and future research on distributed processing system in Internet environment

大数据, 2018
Due to the gradual failure of Moore’s law,traditional centralized data processing systems begin to show performance bottlenecks,which can’t effectively support the rapid development of current business.At the same time,due to the security,cost,policy and
Pengwei MA, Kai WEI, Chunyu JIANG
doaj  

Trust-DETM: Distributed Energy Trading Model Based on Trusted Execution Environment

Mathematics, 2023
The traditional centralized power trading model suffers from high maintenance costs, low processing efficiency and unsynchronized information, and it cannot adapt to the high-frequency and small-dollar distributed energy trading scenario.
Xin Lu, Hongchen Guo
doaj   +1 more source

Performance Testing of Distributed Component Architectures [PDF]

, 2004
Performance characteristics, such as response time, throughput andscalability, are key quality attributes of distributed applications. Current practice,however, rarely applies systematic techniques to evaluate performance characteristics.We argue that ...
Denaro, G, Emmerich, W, Polini, A
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Service Virtualization Using a Non-von Neumann Parallel, Distributed, and Scalable Computing Model

Journal of Computer Networks and Communications, 2012
This paper describes a prototype implementing a high degree of transaction resilience in distributed software systems using a non-von Neumann computing model exploiting parallelism in computing nodes.
Rao Mikkilineni, Giovanni Morana, Daniele Zito, Marco Di Sano   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Convergence-Optimal Quantizer Design of Distributed Contraction-based Iterative Algorithms with Quantized Message Passing

, 2010
In this paper, we study the convergence behavior of distributed iterative algorithms with quantized message passing. We first introduce general iterative function evaluation algorithms for solving fixed point problems distributively.
Cui, Ying, Lau, Vincent K. N.
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Distributed Power Trading Mechanism Based on Blockchain Smart Contracts

Energies
To address the challenges of inefficiency, vulnerability to attacks, and the lack of transparency and fairness in distributed power trading, a distributed power trading mechanism based on blockchain smart contracts is proposed.
Lihua Zhang, Rui Huang, Menglian Jiao, Qingyu Lu, Yi Yang   +4 more
doaj   +1 more source