Results 171 to 180 of about 24,216,259 (358)

CFD–PBM Simulation on Bubble Size Distribution in a Gas–Liquid–Solid Flow Three-Phase Flow Stirred Tank

, 2022
Shuai Li, Runquan Yang, Caili Wang, Hua Han, Shiyu Shen, Huaifa Wang   +5 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

A review of the source, behaviour and distribution of arsenic in natural waters

, 2002
P. Smedley, D. Kinniburgh
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Income Distribution and Macroeconomics

, 1988
Oded Galor, Joseph Zeira
semanticscholar   +1 more source

Modeling of exclusive parton distributions and long-range rapidity correlations in proton-proton collisions at the LHC energies [PDF]

, 2013
V. Kovalenko
openalex   +1 more source

Classic Evans’s Drop Corrosion Experiment Investigated in Terms of a Tertiary Current and Potential Distribution [PDF]

, 2022
Abraham Sainz-Rosales, Xóchitl Ocampo-Lazcarro, Azalia Hernández-Pérez, A. G. González-Gutiérrez, Erika Roxana Larios-Durán, Carlos Ponce de León, Frank C. Walsh, Maximiliano Bárcena-Soto, Norberto Casillas   +8 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Research on joint vehicle routing optimization considering multiple distribution centers. [PDF]

PLoS One
Liu D, Li M, Lei Y, Yu P, Li B, Tang S.
europepmc   +1 more source

Regional distribution of 5α-reductase type 2 in the adult rat brain: An immunohistochemical analysis

, 2012
M. Paola Castelli, Alberto Casti, Angelo Casu, Roberto Frau, Marco Bortolato, Saturnino Spiga, Maria Grazia Ennas   +6 more
openalex   +2 more sources