Results 71 to 80 of about 1,026,061 (247)

Selective capture of iodate anions by a cerium-based metal-organic framework

National Science Open
Effective remediation of radioactive IO3− is highly desirable for fuel reprocessing, medical waste disposal, and nuclear accidents. However, the nature of high solubility, strong mobility, and extremely hard to bind with minerals for IO3− makes this task
Zhao Yuting, Li Jie, Chen Long, Guo Qi, Li Lingyi, He Linwei, Zhai Fuwan, Zhang Mingxing, Chai Zhifang, Wang Shuao   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Influence of Chemical Composition on Concentration Undercooling of Structural Steels [PDF]

Archives of Foundry Engineering
The article studies the undercooling of steel melt around the solid particles, which is one of the main factors determining the rates of nucleation and growth of crystallization centers. Particularly, the effect of chemical composition on this factor for
Y. Aftandiliants, S. Gnyloskurenko, H. Meniailo, V. Khrychikov   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

DEVELOPMENT OF NON-INJECTABLE MEDICINAL DRUGS ACTING ON CNS FOR EMERGENCY THERAPY

Разработка и регистрация лекарственных средств, 2019
Algorithm of selection of compounds and formulations for development of multi-purpose CNS targeted medicinal products for emergency field and civil therapy is justified on the example of potent analgesics.
A. V. Sosnov, F. M. Semchenko, M. I. Vlasov, V. N. Tohmahchi, A. A. Sosnova, A. S. Kinzirsky   +5 more
doaj  

Мониторинг новых бинарных систем экстракции кофеина из природного сырья

Химическая безопасность
Обобщены результаты мониторинга новых бинарных систем экстракции (методом диспергирования) кофеина из природного сырья на примере листьев чая Camellia sinesis L. и бобов Coffea arabica L.
Мельников, А.С., Мещерякова, С.А.   +1 more
doaj   +1 more source

Cadmium distribution coefficeints and Cd transport in structured soils

Plant, Soil and Environment, 2002
In the case of cadmium transport via soil macropores, the short-term duration of an interaction between the reactive solute in aqueous phase and soil, as well as cadmium precipitation or adsorption on particles < 10-5 m should be taken into account ...
Ľ. Lichner, A. Čipáková
doaj   +1 more source