Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Local Polarization Unit Engineering Enables Ultrahigh Energy Density in NBT-Based High-Entropy Ceramic Capacitors. [PDF]
Zhou S +11 more
europepmc +1 more source
From Cure Rate Models to Explainable Survival Analysis: SurvSHAP Based Insights for Credit Risk
ABSTRACT This study proposes a unified credit risk framework that combines mixture cure rate models with time‐varying SurvSHAP(t) explanations. The model separates the risk of default into incidence submodel (whether default occurs) and latency submodel (when default occurs among susceptibles).
Jacob Majakwara
wiley +1 more source
Increased risk of corneal transplant rejection following SARS-CoV-2 infection and vaccination. [PDF]
Allen NE +6 more
europepmc +1 more source
Two cell types (n = 30 cells each) were subjected to calendar aging for up to 323 days at 35 °C and 100% SoC. Noninvasive diagnostic methods and electrode balancing were applied to identify degradation modes, including loss of lithium inventory and loss of active material.
Duc Minh Nguyen +5 more
wiley +1 more source
Fat-tailed dispersal shapes connectivity in a solitary bee. [PDF]
Dorian NN, Crone EE.
europepmc +1 more source
A Response to: Letter to the Editor Regarding "Cost-Effectiveness of Elranatamab Versus Current Therapies for the Management of Patients with Triple-Class Exposed, Relapsed and Refractory Multiple Myeloma, Including Other Bispecific and Physician's Choice of Treatment in Spain". [PDF]
Lozano V +7 more
europepmc +1 more source
A Computational Bayesian Framework for Entropy-Based Inference in the Inverse Gaussian Distribution Under Progressive Type-II Censoring. [PDF]
El-Shahat MAT +4 more
europepmc +1 more source
Drug-associated inflammatory bowel disease: a real-world pharmacovigilance study using the FAERS and JADER databases. [PDF]
Ying Y +8 more
europepmc +1 more source
Post-marketing safety analysis of nafamostat: A retrospective pharmacovigilance study using the Japanese Adverse Drug Event Report (JADER) database. [PDF]
Yin Y, Zhang G.
europepmc +1 more source

