Results 31 to 40 of about 62,192,337 (220)

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

The cramer-von mises test statistic of the generalized extreme value distribution and weibull distribution [PDF]

, 2014
Goodness of fit (GOF) test is a statistical technique in selection of an appropriate probability distribution for a given sample data. This study use a goodness of fit test, which is the Cramer Von Mises (CVM) test, in order to analyze the GEV ...
Abdul Ghani, Nur Hamizah
core  

Adaptive imatinib regimens can mitigate cumulative toxicity while sustaining hemodynamic benefit: A model‐based simulation of the positioning imatinib for pulmonary arterial hypertension trial

British Journal of Clinical Pharmacology, EarlyView.
ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said, Robert B. de Mooij, Dian Jiao, Reitze J. Ovelgonne, Rami Biram, Juan Delgado‐SanMartin, Alexander M. K. Rothman, Sofia S. Villar, Andreas A. Roussakis, Jurjan Aman, Ron A. A. Mathôt, Eleonora L. Swart, Martin R. Wilkins, Imke H. Bartelink   +13 more
wiley   +1 more source

Distribuição de pressão e condutância térmica em contatos de superfícies em junções aparafusadas [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Mecânica.Este trabalho analisa teoricamente e experimentalmente (utilizando-se de dados experimentais obtidos da literatura), a ...
Pereira, Eliete Nascimento
core  

Vine copula knockoffs for variable selection in gene expression studies

Canadian Journal of Statistics, EarlyView.
Abstract Identifying clinical and genetic markers is essential for stratifying cancer patients by survival outcomes and guiding personalized treatment strategies. However, gene expression studies often involve high‐dimensional predictors with mixed data types and complex dependence, which complicates reliable variable selection.
José Ulises Márquez Urbina, Alejandro Román Vásquez, Graciela González Farías, Gabriel Escarela   +3 more
wiley   +1 more source

Nonparametric maximum likelihood estimation of the survival function using current lifetime data

Canadian Journal of Statistics, EarlyView.
Abstract An issue when estimating the failure time survival function is how to set up a prevalent cohort study infrastructure to follow subjects after enrollment. This problem can be circumvented through the well‐known Grenander density estimator using current lifetime observations only.
James H. McVittie, Masoud Asgharian
wiley   +1 more source

Generación de tiempos de falla dependientes weibull bivariados usando cópulas [PDF]

, 2008
La distribución Weibull bivariada es muy importante en confiabilidad y en análisis de supervivencia. La dependencia para este tipo de problemas ha venido cobrando gran importancia en años recientes.
Lopera, Carlos Mario, Jaramillo, Mario César, Manotas, Eva Cristina, Yáñez, Sergio   +3 more
core  

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd), a TROP2‐Directed Antibody‐Drug Conjugate, in Advanced Non‐small Cell Lung Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong, Anna M. Mc Laughlin, Yuzhuo Pan, Sofia Friberg Hietala, Sophie Peigné, Michael Chargualaf, Zoey Tang, Diansong Zhou, Naoyuki Tajima, Malaz Abutarif, Tushar Garimella   +10 more
wiley   +1 more source

The damage and failure mechanism of prestatically loaded rock during medium‐strain rate cyclic impact loading

Deep Underground Science and Engineering, EarlyView.
Based on experimental results and theoretical analysis, an established rock damage accumulation model that comprehensively considers the preapplied static load, impact peak value, impact frequency, and impact times. Abstract To study the rock damage mechanism under high static loading and superimposed medium strain rate cyclic impact loading, a series ...
Wei Wang, Hanpeng Wang, Zicheng Wang, Xinyuan Xie, Yunhao Wu, Jinhou Zhang, Dekang Sun   +6 more
wiley   +1 more source

The generalized inverse Weibull distribution

, 2011
Censored data, Data analysis, Inverse Weibull distribution, Maximum likelihood estimation, Moment, Weibull regression model,
ORTEGA, Edwin M. M., Felipe Gusmão, Edwin Ortega, Gauss Cordeiro, GUSMAO, Felipe R. S. de, CORDEIRO, Gauss M.   +5 more
core   +1 more source