Results 121 to 130 of about 427,721 (311)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Influences of alpine meadow degradation on species diversity and abundance distribution of plant functional groups in Gannan

Xibei zhiwu xuebao
[Objective] To investigate the response of species diversity and richness distribution of plant functional groups to degradation in the Gannan alpine meadow, we analyzed the community construction mechanism and resource utilization of different plant ...
LIU Minxia, LIU Cheng , YANG Chunliang
doaj   +1 more source

Dataset of service life data for 100 building elements and technical systems including their descriptive statistics and fitting to lognormal distribution

, 2021
Kyriaki Goulouti, Didier Favre, Morgane Giorgi, Pierryves Padey, Alina Galimshina, Guillaume Habert, Sébastien Lasvaux   +6 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Active Contours Driven by Multi-Feature Gaussian Distribution Fitting Energy with Application to Vessel Segmentation. [PDF]

PLoS One, 2015
Wang L, Zhang H, He K, Chang Y, Yang X.
europepmc   +1 more source

CONTINUOUSLY DISTRIBUTED FACTORS AFFECTING FITNESS [PDF]

Genetics, 1967
openaire   +2 more sources

Characterization of the Domain Orientations of E. coli 5′-Nucleotidase by Fitting an Ensemble of Conformers to DEER Distance Distributions [PDF]

, 2015
Ulrike Krug, Nathan Alexander, Richard A. Stein, Antje Keim, Hassane S. Mchaourab, Norbert Sträter, Jens Meiler   +6 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Correcting misinterpretations on the distribution of feasible solution lengths in the traveling salesman problem

Dyna
The traveling salesman problem (TSP) is the canonical combinatorial optimization problem famous throughout literature.  There exists an objective function associated with every feasible solution.
Jerry L. Shaw, Donovan Fuqua, Hansuk Sohn, Manuel Ivan Rodriguez-Borbon , Victor Pimentel   +4 more
doaj   +1 more source

[A tooth cone beam computer tomography image segmentation method based on the local Gaussian distribution fitting]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2019
Liu S, Wang Y.
europepmc   +1 more source