Results 71 to 80 of about 641,415 (247)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Ripple Signaling Control for Ancillary Services in Distribution Networks

Turkish Journal of Electrical Power and Energy Systems, 2022
Evangelos Boutsiadis, Dimitrios Tsiamitros, Dimitrios Stimoniaris   +2 more
doaj   +1 more source

Distributed Quantization Networks

, 2012
Several key results in distributed source coding offer the intuition that little improvement in compression can be gained from intersensor communication when the information is coded in long blocks. However, when sensors are restricted to code their observations in small blocks (e.g., 1), intelligent collaboration between sensors can greatly reduce ...
Sun, John Z., Goyal, Vivek K.
openaire   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Assessment of an Adaptive Load Forecasting Methodology in a Smart Grid Demonstration Project

Energies, 2017
This paper presents the implementation of an adaptive load forecasting methodology in two different power networks from a smart grid demonstration project deployed in the region of Madrid, Spain.
Ricardo Vazquez, Hortensia Amaris, Monica Alonso, Gregorio Lopez, Jose Ignacio Moreno, Daniel Olmeda, Javier Coca   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Reliability Assessment of Distribution Networks with Optimal Coordination of Distributed Generation, Energy Storage and Demand Management

Energies, 2019
Modern power distribution networks assume the connection of Distributed Generators (DGs) and energy storage systems as well as the application of advanced demand management techniques.
Alberto Escalera, Edgardo D. Castronuovo, Milan Prodanović, Javier Roldán-Pérez   +3 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Application of Particle Swarm Optimization to a Scheduling Strategy for Microgrids Coupled with Natural Gas Networks

Energies, 2018
This article focuses on the minimization of operational cost and optimal power dispatch associated with microgrids coupled with natural gas networks using particle swarm optimization (PSO). Introducing a natural gas turbine in a microgrid to overcome the
Muhammad Yousif, Qian Ai, Yang Gao, Waqas Ahmad Wattoo, Ziqing Jiang, Ran Hao   +5 more
doaj   +1 more source