Results 151 to 160 of about 910,941 (356)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies [PDF]

, 2009
M.L.A. Oliveira, Clara Fumiko Tachibana Yoshida, Paulo R. Telles, Mariana A. Hacker, Sabrina Alberti Nóbrega de Oliveira, Juliana Custódio Miguel, K. M. R. do Ó, Francisco Inácio Bastos   +7 more
openalex   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Distribution of short and lifetime risks for cardiovascular disease in Italians

European Journal of Preventive Cardiology, 2012
A. Di Castelnuovo, S. Costanzo, M. Persichillo, Marco Olivieri, A. De Curtis, F. Zito, M. Donati, G. de Gaetano, L. Iacoviello   +8 more
semanticscholar   +1 more source

Implied fractional hazard rates and default risk distributions [PDF]

, 2017
Charles S. Tapiero, Pierre Vallois
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Computation of sharp bounds on the distribution of a function of dependent risks

Journal of Computational and Applied Mathematics, 2012
Giovanni Puccetti, L. Rüschendorf
semanticscholar   +1 more source

The Social Cost of Carbon, Risk, Distribution, Market Failures: An Alternative Approach [PDF]

, 2021
Nicholas Stern, Joseph E. Stiglitz
openalex  

Spatial distribution, sources, and risk assessment of heavy metals in sediments from industrial areas in the Kuye River Basin in Shenmu, China [PDF]

, 2023
Zhu Wang, Yong‐Jun Liu, Chun Xiao Wei, Lü Yang, Xingshe Liu, Zhuangzhuang Yang, Aining Zhang, Zhihua Li   +7 more
openalex   +1 more source