Results 131 to 140 of about 24,291,341 (267)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Capital Outflow Controls and Income Distribution in Malaysia
, 2008 The study seeks to analyze the impact of capital outflow controls, imposed by Malaysian government on September 1998, on income distribution. Regression analysis using OLS (Ordinary Least Square), 2SLS (Two Stages Least Square) and GMM (Generalised ...
Duasa, Jarita
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Information matrix test An application using Pareto’s original income distribution data
, 2010 This article attempts to apply and interpret the correspondent Identification Matrix test (White, 1982) for a Pareto type I distribution. One of the most cited datasets used by Pareto, England’s income distribution in 1843 and in 1879, is used.
Mattos, Enlinson, Ponczek, Vladimir
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Testing Special Cases of the GB2 Distribution
We examine the power of hypothesis tests leading to four widely used special cases of the four-parameter generalized beta distribution of the second kind (GB2). These are the Singh-Maddala, Dagum, beta-2 and Fisk distributions.
Hill, R. Carter, Griffiths, William
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, 2000 This paper presents a method of examining the effects of macroeconomic variables on the personal distribution of income over time. The approach involves modeling the complete distribution of income in each year using a flexible functional form from the ...
Creedy, John, Bakker, Alex
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Some Reflections on the Relation Between Finance and Distribution in the 1980s
, 1992 Growth and technological change have created difficulties in linking changes in individual and functional distribution. The problem is complicated by changes in financial structure in the 1980s; making it more difficult to trace the effect on ...
Kregel, J. A.
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source