Results 71 to 80 of about 22,388,357 (300)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Shadow Pricing of Electric Power Interruptions for Distribution System Operators in Finland

Energies, 2018
Increasing distributed generation and intermittencies, along with the increasing frequency of extreme weather events, impose a serious challenge for electric power supply security.
Sinan Küfeoğlu, Niyazi Gündüz, Hao Chen, Matti Lehtonen   +3 more
doaj   +1 more source

Electric-vehicle-enabled hosting capacity enhancement in distribution systems

This chapter presents and thoroughly explores the benefits brought about by a novel strategy, designed from the distribution system operator standpoint, aimed at estimating the distributed generation (DG) hosting capacity in electric distribution systems
Melgar-Dominguez, Ozy D., Sabillon, Carlos, Padilha-Feltrin, Antonio [UNESP], Quijano, Darwin A. [UNESP]   +3 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

POFGEN: a design automation system for VLSI digital filters with invariant transfer function [PDF]

, 1993
The structure, methodology and potential of a new design automation tool, POFGEN, for the generation of fixed function VLSI digital filters is described. The system accepts input data in the form of a coefficient vector and uses this to form a pipelined,
Bull, D R, Bull, DR, Wacey, G, G. Wacey, D.R. Bull   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A comprehensive review of coordinated operation of transmission‐distribution networks: Frameworks, problems and future trends

Energy Conversion and Economics
The rapid growth of distributed energy resources (DERs) is reshaping the operational landscape of transmission and distribution networks, creating new challenges for maintaining system‐wide security, economic efficiency and flexibility.
Yining Yang, Zechun Hu, Ninghui Yang, Alexis P. Zhao, Chenghong Gu   +4 more
doaj   +1 more source

Collaborative Game Theory Between Microgrid Operators and Distribution System Operator Considering Multi-Faceted Uncertainties

Energies
In the vigorous development of the power system, to address the economic challenges of multi-microgrid systems, this paper proposes a Nash bargaining model for collaboration between microgrid operators (MGs) and a distribution system operator (DSO) under
Shuai Wang, Xiaojing Ma, Yaling Yan, Tusongjiang Kari, Wei Zhang   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source