Results 61 to 70 of about 143,004 (304)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Abstract Hidden Markov Models: a monadic account of quantitative information flow

, 2019
Hidden Markov Models, HMM's, are mathematical models of Markov processes with state that is hidden, but from which information can leak. They are typically represented as 3-way joint-probability distributions.
McIver, Annabelle, Morgan, Carroll, Rabehaja, Tahiry   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Optimization of Electric Transformer Operation Through Load Estimation Based on the K-Means Algorithm

Energies
This study presents an innovative methodology to optimize the operation of distribution transformers through the estimation of hourly load curves, aimed at minimizing technical losses due to oversizing, particularly in systems lacking advanced metering ...
Pedro Torres-Bermeo, José Varela-Aldás, Kevin López-Eugenio, Nancy Velasco, Guillermo Palacios-Navarro   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Optimal Operation Of Power Transformers In Power Systems In A Depressed Economy [PDF]

, 2007
Power transformer is one of the most important equipment in an electric power transmission and distribution system. It is very essential in ascertaining the reliability of any power utility.
Ekeh, J.C., lkwu, E.O, Torru, H. R., Wara, S.T.   +3 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

¿ES ECONÓMICO REPARAR TRANSFORMADORES DE DISTRIBUCIÓN?

Revista Científica de Ingeniería Energética, 2011
Se exponen algunas consideraciones económicas que pudieran servir de guía para una evaluación de cuán factiblepuede ser la reparación de transformadores de distribución frente a la compra de unidades nuevas para ...
Orestes Hernández Areu, Dora Terrero Janer   +1 more
doaj  

Smart grids for rural conditions and e-mobility - Applying power routers, batteries and virtual power plants [PDF]

, 2016
Significant reductions of greenhouse gas emission by use of renewable energy sources belong to the common targets of the European Union. Smart grids address intelligent use and integration of conventional and renewable generation in combination with ...
Boehner, Volker, Franz, P., Gallart, R, Girbau Llistuella, Francesc, Hanson, J., Martínez, S., Sumper, Andreas   +6 more
core  

The S-Transform of Distributions [PDF]

The Scientific World Journal, 2014
Parseval’s formula and inversion formula for the S-transform are given. A relation between the S-transform and pseudodifferential operators is obtained. The S-transform is studied on the spaces𝒮(ℝn)and𝒮′(ℝn).
openaire   +3 more sources