Results 51 to 60 of about 574,803 (279)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Improved Measure of Local Chirality

, 2004
It is popular to probe the structure of the QCD vacuum indirectly by studying individual fermion eigenmodes, because this provides a natural way to filter out UV fluctuations.
Andrei Alexandru, Blum, Cundy, DeGrand, Edwards, Frank Lee, Gattringer, Gattringer, Gattringer, Harry B. Thacker, Hasenfratz, Hip, Horváth, Horváth, Horváth, Horváth, Ivan Horváth, Jianbo Zhang, Narayanan, Neuberger, Nilmani Mathur, Shao-Jing Dong, Sonali Tamhankar, Terrence Draper, Ying Chen   +24 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Índice de capacidade do processo na avaliação da irrigação por aspersão Process capacity index in the uniformity evaluation of sprinkler irrigation

Engenharia Agrícola, 2010
Analisar a qualidade da irrigação, além de avaliar seu bom funcionamento, é uma forma de verificar a viabilidade de sua implantação e operação. Como a uniformidade de distribuição é um dos parâmetros mais utilizados para essa avaliação, este trabalho ...
André L Justi, Marcio A Vilas Boas, Silvio C Sampaio   +2 more
doaj   +1 more source

Modeling and Application of Rotary Refractive Sprinkler Head Mobile Spray Water Distribution Calculation Model

Guan'gai paishui xuebao, 2023
【Objective】 Uniformity coefficient is an important parameter in design and operation of sprinkler irrigation. Based on CU and DU, this paper proposed a methods to evaluate whole and local water distribution to help improve design of sprinkler systems and
XUE Shaopeng, GE Maosheng, WEI Fuqiang, ZHANG Qianwen   +3 more
doaj   +1 more source

Copula Calibration [PDF]

, 2013
We propose notions of calibration for probabilistic forecasts of general multivariate quantities. Probabilistic copula calibration is a natural analogue of probabilistic calibration in the univariate setting.
Gneiting, Tilmann, Ziegel, Johanna F.
core   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Variable Pulsed Irrigation Algorithm (VPIA) to Reduce Runoff Losses Under a Low-Pressure Lateral Move Irrigation Machine

Horticulturae, 2019
Due to restrictions and limitations on agricultural water worldwide, one of the most effective ways to conserve water in this sector is to reduce the water losses and improve irrigation uniformity.
Aymen A. Al Al-Baaj, Andrew Lewis
doaj   +1 more source

On Some Dynamical Systems in Finite Fields and Residue Rings

, 2007
We use character sums to confirm several recent conjectures of V. I. Arnold on the uniformity of distribution properties of a certain dynamical system in a finite field. On the other hand, we show that some conjectures are wrong.
Shparlinski, Igor E.
core   +1 more source