Results 51 to 60 of about 135,201 (265)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
EnergiesCylinder-to-cylinder variation (CTCV) is a prevalent issue for natural gas (NG) premixed engines with port fuel injection (PFI), which significantly impacts the engine’s power performance, fuel economy, and reliability. Focusing on this issue, this study
Demin Jia +5 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Experimental Investigation on the Distribution Performance of Refrigerant Distributors
Zhileng xuebao, 2014 Refrigeration mal-distribution in a distributor located at the inlet of a heater exchanger plays an important role in the heat exchanger performance. This paper proposes a test method to measure the mass flow rate and quality of each branch tube after ...
Han Qing +3 more
doaj
Evaluating the hydraulic performance of rotating spray plate sprinklers
Journal of Agricultural EngineeringThe current study was design to evaluate the performance of rotating spray plate sprinklers, R3000 with three nozzle sizes i.e., #16-N1, #24-N2 and #32-N3 corresponding to 3.18, 4.76 and 6.35 mm diameters, respectively using various combinations of ...
Zawar Hussain +4 more
doaj +1 more source
Exceptional Sets in Uniform Distribution [PDF]
Proceedings of the Edinburgh Mathematical Society, 1979 Let B be a measurable set of real numbers in (0,1) of Lebesgue measure |B| and letx1, …,xnbe real. Thendenotes the number ofj(1 ≦j≦n) for which the fractional part {xj}∈B. Thediscrepancyofx1, …,xniswhere the supremum is taken over all intervalsIin [0,1].
openaire +1 more source