Results 81 to 90 of about 135,201 (265)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Examining the Uniformity of Flow Distribution in Manifolds [PDF]

open access: yesJournal of Applied Fluid Mechanics
Flow distribution uniformity in manifolds is important in various engineering applications. In this study, the effect of manifold design on flow distribution is examined using both experimental and numerical methods.
F. Yazici   +3 more
doaj   +1 more source

Effect of a Surfactant Additive on Drug Transport and Distribution Uniformity After Aerosol Delivery to Ex Vivo Lungs. [PDF]

open access: yesJ Aerosol Med Pulm Drug Deliv, 2022
Hages ND   +10 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Flow Distribution Characteristics of Supercritical Hydrocarbon Fuel in Parallel Channels with Pyrolysis

open access: yesXibei Gongye Daxue Xuebao, 2019
Due to the asymmetric geometry of flowpath and combustion organization, the heat flux distribution on RBCC's walls are extremely non-uniform. With a validated numerical model considering the changes of thermophysical properties and chemical components ...

doaj   +1 more source

On Weyl's criterion for uniform distribution.

open access: yesMichigan Mathematical Journal, 1963
Es sei \(\{s_n (x)\}\) eine unendliche Folge von Funktionen, die auf einem Intervall \(a \leq x \leq b\) beschränkt und integrabel sind. \(S(N,x,m) = {1 \over N} \sum_{n=1}^N \exp (2 \pi i m s_n(x))\) (\(m\) ganz, \(\neq 0\)) seien die Weylschen Summen. Weiter sei \(I(N,m) = \int_a^b |S(N,x,m)|^2 \,dx\).
Davenport, H.   +2 more
openaire   +2 more sources

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