Results 51 to 60 of about 414,828 (301)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Evolution of Ecological Environment Quality in Metropolitan Suburbs and Its Interaction with Tourism Development: The Case of Huangpi District, Wuhan City

Land
Tourism has been a key factor in the economic growth of metropolitan suburbs. However, tourism development (TD) frequently precipitates ecological challenges, which are compounded by the absence of scientific frameworks for quantifying TD’s impact on ...
Danli Yang, Shuangyu Xie, Jianwei Sun, Huafang Qiao, Jiaxiao Feng, Xiaoyi Xie   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Magnitude and determinant factors of traditional uvulectomy practices among children under the age of five in Lemo District, Central Ethiopia

Scientific Reports
Traditional uvulectomy, a widely practiced procedure in many parts of the world including Ethiopia, poses significant health risks to children under five.
Tamiru Belachew, Wudit Wasu, Selamu Abose, Tigist Enyew, Alemu Earsido, Mulatu Abageda   +5 more
doaj   +1 more source

Modeling Electoral Coordination: Voters, Parties and Legislative Lists in Uruguay [PDF]

, 2013
types: ArticleDuring each electoral period, the strategic interaction between voters and political elites determines the number of viable candidates in a district.
Katz, Gabriel, Levin, I
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Pengaruh Kompetensi Pedagogik dan Profesionalisme Guru Terhadap Prestasi Belajar Siswa Pada SMA se-Kecamatan Amalatu-Elpaputih

Edukasia
The impact of teachers's pedagogical competence and professionalism on student learning achievement in high school in Amalatu-Elpaputih District. A teacher's pedagogical and professional competence is needed to improve the quality of learning and ...
Viona Wairatta, Th. Laurens, A. Sahalessy, Sumarni Rumfot   +3 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Comparative politics of strategic voting : a hierarchy of electoral systems [PDF]

, 2004
What is the impact of electoral rules on the way people make decisions in the voting booth? Traditionally the literature about electoral systems argues that the size of the district magnitude determines the amount of strategic voting.
Gschwend, Thomas
core   +1 more source