Results 41 to 50 of about 1,208,916 (313)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A discrete districting plan

Networks & Heterogeneous Media, 2019
The outcome of elections is strongly dependent on the districting choices, making thus possible (and frequent) the gerrymandering phenomenon, i.e.\ politicians suitably changing the shape of electoral districts in order to win the forthcoming elections.
Saracco A., Saracco G.
openaire   +5 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Effects of Tree Species and Layout on the Outdoor Thermal Environment of Squares in Hot-Humid Areas of China

Buildings, 2022
Planting trees is an effective way to regulate the outdoor thermal environment and combat urban heat islands (UHIs). Tree species and layout can have a considerable effect on, for example, the outdoor shading and wind fields, and finally the distribution
Jiahao Yang, Yang Zhao, Yukai Zou, Dawei Xia, Siwei Lou, Wang Liu, Kefu Ji   +6 more
doaj   +1 more source

Study of the coupling effect of CO2 and PM2.5 emissions: A case study of yangtze river delta, China

Heliyon
Many countries are confronted with the dual challenge of mitigating CO2 emissions and controlling PM2.5 pollution, attributed to the impacts of global climate change.
Wengin Chung, Chao Liu
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Thermal Resilience of Public Building Atriums Under Different States During Heatwaves

Buildings
Under the influence of climate change, extreme heat events are becoming more frequent and intense. Understanding the response mechanisms of public building spaces, such as atriums, during extreme heat events is of great significance for developing ...
Guangyi Zhang, Linxue Li, Yang Yu, Jinhao Liu, Qi Zhang   +4 more
doaj   +1 more source

Improving the Thermal Comfort of an Open Space via Landscape Design: A Case Study in Hot and Humid Areas

Atmosphere, 2022
Hot and humid areas experience constant high temperatures and high humidity during summer, causing widespread concern about outdoor thermal discomfort.
Jiahao Yang, Yang Zhao, Yukai Zou, Dawei Xia, Siwei Lou, Tongye Guo, Zhengnan Zhong   +6 more
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source