Results 141 to 150 of about 1,788,937 (345)

Behavioral Disturbances in Dementia and Beyond: Time for a New Conceptual Frame? [PDF]

open access: gold, 2019
Federico Ambrogio   +3 more
openalex   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Imprints of land use history and disturbance regime in phylogenetic diversity of Mediterranean plant communities

open access: yesEcosphere
Mediterranean landscapes were drastically affected by high levels of abandonment of agricultural and other land practices during the last century. These changes in land use can have significant effects on diversity patterns by altering disturbance and ...
Anna Mastrogianni   +5 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

ANTHOCYANINS IN STRAWBERRY POLYPHENOLIC EXTRACT AMELIORATE METABOLIC DISTURBANCES IN RATS FED A DIET HIGH IN FAT

open access: gold, 2016
Jerzy Juśkiewicz   +6 more
openalex   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy