Results 41 to 50 of about 576,419 (267)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

When Trees Are Not an Option: Perennial Vines as a Complementary Strategy for Mitigating the Summer Warming of an Urban Microclimate

open access: yesBuildings
This study evaluates the potential of Boston Ivy (Parthenocissus tricuspidata) to reduce building surface temperature in a mid-latitude North American city center where vine use for this purpose is uncommon.
Andrew A. Millward, Michelle Blake
doaj   +1 more source

Quantifying carbon and species dynamics under different fire regimes in a southeastern U.S. pineland

open access: yesEcosphere, 2019
Forests have a prominent role in carbon sequestration and storage. Climate change and anthropogenic forcing have altered the dominant characteristics of some forested ecosystems through changes to their disturbance regimes, particularly fire.
Steven A. Flanagan   +12 more
doaj   +1 more source

Long-Term Suppression of Hardwood Regeneration by Chinese Privet (Ligustrum sinense)

open access: yesFrontiers in Forests and Global Change, 2022
Native hardwood regeneration in the southeast United States is hindered by repeat disturbance events and the presence of invasive species. Our study aimed to determine the ability of native species in an unmanaged urban forest fragment to persist ...
Taylor N. Turner   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Rapid Initial Community Builder (RICB) V1.1 for LANDIS-II

open access: yesMethodsX
Forest succession, or ecosystem process models, can aid in many land management decisions as they inherently incorporate ecological processes to predict how disturbances impact the resilience of the forest and its potential future structure.
Steven A Flanagan   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

DISTURBING CEMETERIES. [PDF]

open access: yesThe Lancet, 1896
n ...
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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