Results 51 to 60 of about 8,607,501 (196)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Climate, Environment, and Disturbance History Govern Resilience of Western North American Forests

Frontiers in Ecology and Evolution, 2019
Before the advent of intensive forest management and fire suppression, western North American forests exhibited a naturally occurring resistance and resilience to wildfires and other disturbances.
Paul F. Hessburg, Paul F. Hessburg, Carol L. Miller, Sean A. Parks, Nicholas A. Povak, Alan H. Taylor, Philip E. Higuera, Susan J. Prichard, Malcolm P. North, Brandon M. Collins, Matthew D. Hurteau, Andrew J. Larson, Craig D. Allen, Scott L. Stephens, Hiram Rivera-Huerta, Camille S. Stevens-Rumann, Lori D. Daniels, Ze'ev Gedalof, Robert W. Gray, Van R. Kane, Derek J. Churchill, R. Keala Hagmann, Thomas A. Spies, C. Alina Cansler, R. Travis Belote, Thomas T. Veblen, Mike A. Battaglia, Chad Hoffman, Carl N. Skinner, Hugh D. Safford, R. Brion Salter   +30 more
doaj   +1 more source

Forest plant and bird communities in the Lau Group, Fiji. [PDF]

PLoS ONE, 2010
We examined species composition of forest and bird communities in relation to environmental and human disturbance gradients on Lakeba (55.9 km²), Nayau (18.4 km²), and Aiwa Levu (1.2 km²), islands in the Lau Group of Fiji, West Polynesia.
Janet Franklin, David W Steadman
doaj   +1 more source

Appendix E. Maps of canopy gaps for the four disturbance history plots.

, 2016
Maps of canopy gaps for the four disturbance history ...
Milan Kobal (2909900), Thomas A. Nagel (2909903), Miroslav Svoboda (802074)   +2 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Disturbances can control fine-scale pedodiversity in old-growth forests: is the soil evolution theory disturbed as well? [PDF]

Biogeosciences, 2014
Biota–soil interactions in natural ecosystems are the subject of considerable research. Our hypothesis is that individual trees play a significant role through biomechanical and biochemical disturbances affecting soil formation in temperate forests ...
P. Šamonil, I. Vašíčková, P. Daněk, D. Janík, D. Adam   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Extending Canadian forest disturbance history maps prior to 1985

Ecosphere
An accurate depiction of wildfire, harvesting, and insect outbreak disturbances is essential for sustainable ecosystem management of forests in Canada. Even though the advent of temporally consistent 30‐m resolution Landsat data has enabled the detailed ...
David L. P. Correia, Luc Guindon, Marc‐André Parisien   +2 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source