Results 81 to 90 of about 1,718,009 (282)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

NON-LINEAR OBSERVER-BASED CONTROL OF FLEXIBLE-JOINT MANIPULATORS USED IN MACHINE PROCESSING [PDF]

, 2012
Lien vers la version éditeur: http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleid=1727347&resultClick=3This paper proposes to use a non-linear observer to build the state and the external force of flexible manipulator robots ...
ABBA, Gabriel, Jinna Qin, QIN, Jinna, François Léonard, Gabriel Abba, LEONARD, François   +5 more
core   +1 more source

Study on deformation law of roadway surrounding rock under dynamic disturbance

Meikuang Anquan
The surrounding rock is in a state of high stress during deep mining of coal mine, and the dynamic disturbance may lead to the instability of the surrounding rock and even rock burst.
Mingkun LUO, Liqiang SONG, Siqi LI, Dongdong SONG, Anchang LAN, Ce JIA, Sheng LI, Zhenhua YANG, Changyou WANG   +8 more
doaj   +1 more source

Analgesic Prescription Patterns and Pain Outcomes in Southeast Asia: Findings From the Analgesic Treatment of Cancer Pain in Southeast Asia Study

Journal of Global Oncology, 2018
Purpose: To identify patterns of analgesic prescription and to explore patient-reported pain intensity, sleep disturbance, and quality of life among cancer patients with pain in Southeast Asia (SEA).
Dang Huy Quoc Thinh, Wimonrat Sriraj, Marzida Mansor, Kian Hian Tan, Cosphiadi Irawan, Johan Kurnianda, Yen Phi Nguyen, Annielyn Ong-Cornel, Yacine Hadjiat, Hanlim Moon, Francis O. Javier   +10 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Ice disturbance intensity structures benthic communities in nearshore Antarctic waters [PDF]

, 2007
Ice scouring is one of the 5 most significant natural forces acting on ecosystems, yet very few data exist linking the intensity of ice disturbance with parameters of benthic community structure.
Smale, DA, Smale, Dan A.
core   +2 more sources

Active disturbance rejection switching control of quadrotor based on robust differentiator

Systems Science & Control Engineering, 2020
To solve the problem of trajectory tracking control of a quadrotor unmanned aerial vehicle (UAV) under white noise disturbance, a new active disturbance rejection control (ADRC), an active disturbance rejection switching control (ADRSC) algorithm of the ...
Jiawei Zhao, Hongli Zhang, Xinkai Li
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source