Results 71 to 80 of about 1,713,738 (281)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Carbon redistribution by erosion processes in an intensively disturbed catchment [PDF]

CATENA, 2017
Peer ...
Boix-Fayos, Carolina, Martínez-Mena García, M. Dolores, Pérez-Cutillas, Pedro, de Vente, Joris, González Barberá, Gonzalo, Mosch, Wouter, Navarro-Cano, J. A., Gaspar Ferrer, Leticia, Navas Izquierdo, Ana   +8 more
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Enriching plant diversity in grasslands by large-scale experimental sward disturbance and seed addition along gradients of land-use intensity

, 2016
Aims The relationship between biodiversity and ecosystem functioning is among the most active areas of ecological research. Furthermore, enhancing the diversity of degraded ecosystems is a major goal in applied restoration ecology.
Klaus, Valentin H., Kleinebecker, Till, Hölzel, Norbert, Schäfer, Deborah, Prati, Daniel, Fischer, Markus   +5 more
core   +1 more source

Habitat-mediated facilitation and counteracting ecosystem engineering interactively influence ecosystem responses to disturbance [PDF]

, 2011
Recovery of an ecosystem following disturbance can be severely hampered or even shift altogether when a point disturbance exceeds a certain spatial threshold. Such scale-dependent dynamics may be caused by preemptive competition, but may also result from
Zee, Els M. van der, Zee, Els M. van der,, van der Heide, Tjisse; id_orcid, van der Heide, Tjisse, Eriksson, Britas Klemens; id_orcid, van der Heide, T., Eriksson, B.K., O'Hara, R., O'Hara, Robert, Tjisse van der Heide, Heide, Tjisse van der,, Johan S. Eklöf, Johan S Eklöf, Serena Donadi, Eklöf, Johan,, O\u27Hara, R., Robert O'Hara, Eklöf, Johan S., Heide, Tjisse van der, Els M van der Zee, Eklöf, Johan, Eklöf, J.S., O´Hara, Robert, van der Zee, Els, O’Hara, Robert,, Els M. van der Zee, Eklöf, Johan S.,, Eriksson, Britas Klemens, Donadi, Serena, Britas Klemens Eriksson, O'Hara, Robert B., van der Zee, Els M., Donadi, Serena,, van der Zee, E.M., Eriksson, Britas Klemens,, Donadi, S.   +35 more
core   +3 more sources

High species richness of sheep‐grazed sand pastures is driven by disturbance‐tolerant and weedy short‐lived species

Ecology and Evolution
We selected 15 sheep‐grazed sand pastures along a gradient of increasing grazing intensity to study the fine‐scale patterns of main biomass fractions (green biomass, litter) and that of plant species and functional groups (life forms and social behaviour
Gergely Kovacsics‐Vári, Judit Sonkoly, Katalin Tóth, Andrea McIntosh‐Buday, Patricia Elizabeth Díaz Cando, Viktória Törő‐Szijgyártó, Nóra Balogh, Luis Roberto Guallichico Suntaxi, Francis David Espinoza Ami, Gábor Matus, Béla Tóthmérész, Péter Török   +11 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

SPECIES SIMILARITY - DISTANCE RELATIONSHIP IN WETLANDS: EFFECT OF DISTURBANCE INTENSITY

, 2009
Disturbance is considered to be one of the main factors influencing variations in species diversity. While many experimental and observational studies provide a good understanding of how disturbance maintains the alpha-diversity, we know little about how
Lu, T, Fu, BJ, Zhang, YX, Ni, HW, Ma, KM, Ma, KM, Chinese Acad Sci, State Key LUrban & Reg Ecol, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China.   +5 more
core